What is Epidermal Growth Factor (EGF)? How do Growth Factors in Skincare Work?

What is Epidermal Growth Factor (EGF)? How do Growth Factors in Skincare Work?
Epidermal Growth Factor (EGF)

What is EGF in skincare?

EGF is a naturally occurring protein in your skin. It is occasionally called Growth Factor and scientifically (or if you're looking at an ingredient list in skincare), it’s known as sh-oligopeptide-1.

EGF, functions by stimulating cell regeneration when skin has been damaged by a cut, sunburn, etc. This activation of new cell generation simulates cells called fibroblasts, which produce collagen, hyaluronan, and elastin.

What is EGF made from?

Our EGF is made through a process called protein expression, which has been used for over thirty years. In protein expression, synthetic DNA teaches bacteria how to produce EGF that is identical to human EGF. When EGF is put on the skin, it takes cues from surrounding tissues to become that type of cell, so it generates new, younger-looking skin.

As mentioned above, EGF is a natural protein and supports your skin’s natural signaling properties. You are born with EGF, but similar to collagen, the amount of EGF in your skin decreases as your age increases (starting at the young age of 25!)

What does EGF Serum do for your skin?

It’s called the “Fountain of Youth” in skincare for many reasons! Unlike retinol, “the Gold Standard” in skincare, EGF can be used on sensitive skin. Here are some of the other wonderful benefits of EGF Serum for skin:

  • Constantly boosts cell turnover, which results in skin that looks and feels rejuvenated.
  • Smooths the appearance of wrinkles by stimulating collagen and elastin to improve the skin’s texture and elasticity.
  • Restores the skin’s youthful thickness, smoothness, plumpness, and tone.
  • Strengthens the skin’s barrier to hold moisture and maintain optimal hydration.
  • Accelerates the fading of acne scars and inflammation.
  • Reduces skin pigmentation concerns, like age spots.
  • Reinforces the skin’s protective mechanisms to combat signs of aging.
  • Enhances the skin’s natural recovery process after professional treatments including microneedling, chemical peels, and laser treatments.

In a Bioeffect research study to see if an EGF Serum (not KRS) worked as they claimed, 30 women applied the serum to half of their face twice a day for eight weeks. They used a placebo that was the same serum but without EGF on the other side of their face. At the completion of eight weeks, the thickness of the skin on the side of the face where EGF Serum was used had increased more than 60%.

Can EGF Serum be used with collagen?

YES! Actually, the benefits of EGF Serum are even more pronounced when used with Collagen Booster Intense Repair Serum! These two products are a powerful pair of anti-aging products that work together to increase collagen production, initiate regeneration, and restore skin damaged by aging, blemishes or sun damage.

Can you use EGF Serum with Vitamin C Serum?

Another YES! When used together correctly, EGF Serum works really well with Vitamin C Serum! Because EGF Serum contains complex ingredients that can be damaged by acid, we recommend that you first apply Vitamin C Serum, and then wait at least 15 minutes before applying the EGF Serum. Then the EGF Serum can get to work replenishing skin cells, which makes these two products a terrific team!

Can you use EGF with retinol?

YES again! EGF Serum and retinol can be used together, and yield even better results than when used alone! Collectively, the ingredients have been found to increase the effectiveness of anti-aging skincare regimens. Additionally, EGF helps buffer the skin from some of retinol’s potential side effects.

It is recommended that EGF is applied to clean, dry skin first. The best results are seen when Vitamin C Serum is used in the morning, and then EGF Serum and Retinol Evening Renewal Serum are layered at night. 

Can EGF be used with microneedling?

YES! YES! YES! EGF can be used both before and after microneedling! In fact, EGF has been found to enhance the efficacy of microneedling as well as reduce any down time. Following microneedling, you can use EGF Serum at home to maximize the effects of the treatment.

Is EGF Serum safe?

When used topically for skincare, there are no known side effects of EGF. EGF and other ingredients we use in our products are designed to accelerate the production of new skin cells. Melanoma does not have a receptor for EGF, but we do not recommend the use of EGF or any other nutritional product on areas affected by cancer as 'feeding' those cells is a very bad idea. Users with a history of skin cancer should have any products (with or without EGF) approved by their doctor.

What skin types are best for EGF Serum?

Kate Ryan Skincare’s EGF Serum is for individuals with any skin type that is showing visible signs of aging. It is also for anyone who wants to prevent or repair loss of firmness, lines or wrinkles.

How do you apply EGF Serum?

EGF Serum can be applied once daily to clean, dry skin. You should allow EGF Serum to absorb into your skin before applying other serums and moisturizers.

Why should I choose Kate Ryan Skincare’s EGF Skin Rejuvenation Serum?

First, the ingredients in Kate’s EGF Serum are superior. The amount of EGF in the product along with the supporting amino acids and cell growth enhancers are reason alone. But if that isn’t enough, we invite you to do a cost comparison. Most EGF serums cost well over $100 and don’t contain the same number of high-quality ingredients. Kate’s EGF Serum is a fraction of the cost – and we are pretty sure that you will agree with us that it is worth every penny!

Speaking of pennies - you can save a few (500 to be exact!) on the purchase of our EGF Serum using promo code: SAVE5  - Save $5 when you purchase our EGF Serum as our way of saying thanks for stopping by....


We love talking with our customers about skincare and are happy to answer your questions. Please email us at hello@kateryanskincare.com.